J Hematol

Journal of Hematology, ISSN 1927-1212 print, 1927-1220 online, Open Access

Article copyright, the authors; Journal compilation copyright, J Hematol and Elmer Press Inc

Journal website https://jh.elmerpub.com

Case Report

Volume 15, Number 3, June 2026, pages 162-168

Chronic Eosinophilic Leukemia Not Otherwise Specified: A Case Series

Figures

↓ Figure 1. Peripheral blood smear with dysplastic eosinophils, noting the abnormal nuclear contours in a subset of the eosinophils and the atypical uneven granulation at × 20 magnification.

↓ Figure 2. Peripheral blood with dysplastic eosinophils, noting the completely separated nuclear lobes, and the cytoplasm with less than 50% of typical granulation in the bottom most eosinophil at × 60 magnification.

↓ Figure 3. Bone marrow aspirate smear with focally increased eosinophil precursors with uneven granulation at × 40 magnification.

↓ Figure 4. Core bone marrow biopsy with increased eosinophil precursors (mononuclear to bilobed cells with deep eosinophilic cytoplasm) at × 40 magnification.

Tables

↓ **Table 1.** Lab Values of Case 1
	2020 (original consultation)	2024 (second consultation)	2024 (starting on TKI)	2024 (1 month after TKI)	2025 (3 months after TKI)
TKI: tyrosine kinase inhibitor.
White blood cell count	18.1 × 10³/µL	32.3 × 10³/µL	19.5 × 10³/µL	24.8 × 10³/µL	26.0 × 10³/µL
Absolute eosinophil count	9.1 × 10³/µL	9.4 × 10³/µL	11.6 × 10³/µL	13.8 × 10³/µL	14.6 × 10³/µL
Hemoglobin	15.3 g/dL	14.9 g/dL	13.2 g/dL	13.5 g/dL	12.7 g/dL
Platelet count	160 × 10³/µL	171 × 10³/µL	138 × 10³/µL	135 × 10³/µL	146 × 10³/µL

↓ **Table 2.** Lab Values of Case 2
	2017 (original consultation)	2023 (CVA)	2025 (atrial fibrillation diagnosis and stopped TKI)	2025 (1 month after cessation of TKI)	2025 (5 months after TKI)
CVA: cerebrovascular accident; TKI: tyrosine kinase inhibitor.
White blood cell count	11.7 × 10³/µL	8.9 × 10³/µL	7.5 × 10³/µL	7.7 × 10³/µL	7.2 × 10³/µL
Absolute eosinophil count	0.1 × 10³/µL	0.1 × 10³/µL	0.2 × 10³/µL	0.2 × 10³/µL	0.2 × 10³/µL
Hemoglobin	17.1	16.4	17.3	18.5	16.5
Platelet count	173	172	167	164	160