Figures

Figure 1. PRISMA chart of the reported studies showing the search selection strategy and exclusion criteria. PRISMA: Preferred Reporting Items for Systematic Reviews and Meta-Analyses.

Figure 2. Forest plot of splenic response rate. NCT identifiers correspond to: NCT02101268 - SIMPLIFY-2; NCT01969838 - SIMPLIFY-1; NCT04173494 - MOMENTUM. CI: confidence interval.

Figure 3. Forest plot of transfusion independence. NCT identifiers correspond to: NCT02101268 - SIMPLIFY-2; NCT01969838 - SIMPLIFY-1; NCT04173494 - MOMENTUM. CI: confidence interval.

Figure 4. Forest plot of transfusion dependence. NCT identifiers correspond to: NCT02101268 - SIMPLIFY-2; NCT01969838 - SIMPLIFY-1; NCT04173494 - MOMENTUM. CI: confidence interval.

Figure 5. Forest plot of TSS response rate. NCT identifiers correspond to: NCT02101268 - SIMPLIFY-2; NCT01969838 - SIMPLIFY-1; NCT04173494 - MOMENTUM. CI: confidence interval; TSS: total symptom score.