Journal of Hematology, ISSN 1927-1212 print, 1927-1220 online, Open Access
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Case Report

Volume 14, Number 5, October 2025, pages 267-272

Acute Undifferentiated Leukemia Presented With Mediastinal Sarcoma

Figures

Figure 1.
Figure 1. Bone marrow aspirate (a, b, c) showing the blasts infiltrating the bone marrow, the morphology is more toward myeloid leukemia. Bone marrow biopsy (d, e) showing diffuse total infiltration by blasts.
Figure 2.
Figure 2. Flow cytometry of acute undifferentiated leukemia case showing blast population (red) positive for CD45 (a), negative for lineage-specific antigen (b, c, d), negative for T-cell markers (e, f), positive for CD7 (g, h), positive for primitive markers, which are CD34, HLA-DR, and CD38, and negative for CD117 (i, j, k), positive for only one myeloid marker CD33 (l), and negative for all other markers (m, n, o, p, q, r, s, t). HLA-DR: human leukocyte antigen-DR isotype.

Table

Table 1. Timeline of the Case
 
Time pointEventDescription
SOB: shortness of breath; CXR: chest X-ray; CT: computed tomography; PET: positron emission tomography; AUL: acute undifferentiated leukemia.
Day 0Patient presented with SOBCXR showed right pleural effusion
Day 5PleurocentesisExudative fluid
Day 8EchocardiogramPericardial effusion
Day 15Chest CT scanPosterior mediastinal mass
Day 18Mediastinal mass biopsyMyeloid sarcoma
Day 19PET scanBulky hypermetabolic mediastinal mass with bone marrow hyperactivity
Day 28Bone marrow aspirateAUL