Journal of Hematology, ISSN 1927-1212 print, 1927-1220 online, Open Access
Article copyright, the authors; Journal compilation copyright, J Hematol and Elmer Press Inc
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Case Report

Volume 14, Number 5, October 2025, pages 273-280

Fever: Harmless Heat or a Deadly Inferno? Unmasking Hemophagocytic Lymphohistiocytosis and Beyond: A Rare Case of Mast Cell Sarcoma and Overview of HLH

Figure

Figure 1.
Figure 1. Day-by-day hospital course with corresponding management. HLH: hemophagocytic lymphohistiocytosis; IL-2R: interleukin 2 receptor; EEG: electroencephalogram; FISH: fluorescence in situ hybridization; IVIG: intravenous immunoglobulin; CT: computed tomography; DNR: do-not-resuscitate.

Table

Table 1. Genetic Analysis Results
 
GeneVariant detectedAmino acid changeVariant frequency (0%)Clinical impact
ASXL1c.1772_1842del71p.Tyr591CysfsX477Tier 1
KITc.2447A>Tp.Asp816Val39Tier 1
TET2c.620delTp.Met207SerfsX4349Tier 1
EZH2c.2069G>Ap.Arg690His44Tier II