Journal of Hematology, ISSN 1927-1212 print, 1927-1220 online, Open Access
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Case Report

Volume 14, Number 5, October 2025, pages 273-280

Fever: Harmless Heat or a Deadly Inferno? Unmasking Hemophagocytic Lymphohistiocytosis and Beyond: A Rare Case of Mast Cell Sarcoma and Overview of HLH

Figure

↓  Figure 1. Day-by-day hospital course with corresponding management. HLH: hemophagocytic lymphohistiocytosis; IL-2R: interleukin 2 receptor; EEG: electroencephalogram; FISH: fluorescence in situ hybridization; IVIG: intravenous immunoglobulin; CT: computed tomography; DNR: do-not-resuscitate.
Figure 1.

Table

↓  Table 1. Genetic Analysis Results
 
Gene Variant detected Amino acid change Variant frequency (0%) Clinical impact
ASXL1 c.1772_1842del71 p.Tyr591CysfsX4 77 Tier 1
KIT c.2447A>T p.Asp816Val 39 Tier 1
TET2 c.620delT p.Met207SerfsX43 49 Tier 1
EZH2 c.2069G>A p.Arg690His 44 Tier II