Figure 1. Serum ferritin level trends pre- and post-transition to RBCX. Serum ferritin levels were trended for patients at 3-month intervals which showed ferritin stability or improvement as patients continued RBCX. RBCX: red blood cell exchange.
| Journal of Hematology, ISSN 1927-1212 print, 1927-1220 online, Open Access |
| Article copyright, the authors; Journal compilation copyright, J Hematol and Elmer Press Inc |
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Original Article
Volume 14, Number 4, August 2025, pages 210-213
Novel Red Blood Cell Exchange Parameters for Treatment of Transfusion-Dependent Thalassemia Based on Experience of Five Patients
Figure
Tables
| Parameter | TDT RBCX | SCD RBCX |
|---|---|---|
| Pre- and post-transfusion hematocrit targets were higher for TDT patients when compared to SCD parameters while the FCR goal was the same for both groups. FCR: fraction of cells remaining; RBCX: red blood cell exchange; SCD: sickle cell disease; TDT: transfusion-dependent thalassemia. | ||
| Transfusion interval (weeks) | 4 - 6 | 4 - 7 |
| Pre-transfusion hematocrit | 29 (Hb 9.5 g/dL or higher) | 25 - 27 |
| Post-transfusion hematocrit target | 37 - 38 | 30 in acute states; 32 - 34 in chronic exchanges |
| Isovolemic hemodilution | Omitted | Performed, if pre-transfusion hematocrit allows |
| FCR | 30 | 30 |
| Patient | Mean ferritin pre-RBCX (1 year prior) | Mean ferritin post-RBCX (1 year post) | Difference in ferritin | Blood utilization pre-RBCX (mL) | Blood utilization post-RBCX (mL) | Simple transfusion interval (weeks) | RBCX transfusion interval (weeks) |
|---|---|---|---|---|---|---|---|
| Mean serum ferritin decreased for the five patients once transitioned to chronic RBCX. Blood utilization (mL) increased on chronic RBCX while transfusion intervals (described in weeks) increased. RBCX: red blood cell exchange. | |||||||
| A | 6,530 | 1,382 | 5,148 | 4,200 | 5,625 | 2 | 4 |
| B | 1,220 | 880 | 340 | 2,400 | 8,100 | 4 | 5 |
| C | 1,076 | 633 | 443 | 1,200 | 5,200 | 3 | 5 |
| D | 2,503 | 2,118 | 385 | 1,800 | 7,700 | 4 | 6 |
| E | 2,718 | 1,282 | 1,436 | 1,500 | 4,900 | 3 | 5 |