Journal of Hematology, ISSN 1927-1212 print, 1927-1220 online, Open Access
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Case Report

Volume 14, Number 2, March 2025, pages 94-99

Phosphatidylinositol 3-Kinase Inhibition and Allogeneic Stem Cell Transplantation Can Overcome Chemotherapy Resistance in Refractory Burkitt Lymphoma

Figures

Figure 1.
Figure 1. Initial positron emission tomography-computed tomography (PET-CT) scan. Maximum intensity projection (MIP) with fused PET-CT images and corresponding CT images at the C2 and S1 vertebral levels.
Figure 2.
Figure 2. (a) Hematoxylin and eosin-stained sections (× 400) of the left neck biopsy shows Burkitt lymphoma with diffuse proliferation of monotonous atypical lymphoid cells with scattered tingible body macrophages (starry sky pattern), frequent apoptotic bodies, and mitotic figures. (b) Immunohistochemistry (× 400) for phosphorylated AKT is positive on the neoplastic cells in a nuclear staining pattern.
Figure 3.
Figure 3. Positron emission tomography-computed tomography (PET-CT) scan following chemotherapy and copanlisib. Maximum intensity projection (MIP) with fused PET-CT images and corresponding CT images at the C2 and S1 vertebral levels.
Figure 4.
Figure 4. Complete remission positron emission tomography-computed tomography (PET-CT) scan 3 months post-transplant. Maximum intensity projection (MIP) with fused PET-CT images and corresponding CT images at the C2 and S1 vertebral levels.