Journal of Hematology, ISSN 1927-1212 print, 1927-1220 online, Open Access
Article copyright, the authors; Journal compilation copyright, J Hematol and Elmer Press Inc
Journal website https://jh.elmerpub.com

Case Report

Volume 14, Number 1, February 2025, pages 32-37

A Rare Case of Acute Aleukemic Mast Cell Leukemia With Osteoblastic Lesions in the Appendicular Skeleton

Figures

Figure 1.
Figure 1. CT chest with contrast showing the osteoblastic lesions in the ribs (a) and vertebrae (b) (arrows). CT: computed tomography.
Figure 2.
Figure 2. CT abdomen and pelvis with contrast showing the pelvic osteoblastic lesions (arrows). CT: computed tomography.
Figure 3.
Figure 3. CT abdomen and pelvis with contrast showing hepatosplenomegaly and dilated portal vein (arrows). CT: computed tomography.
Figure 4.
Figure 4. Bone marrow biopsy showing atypical mast cells (arrows).
Figure 5.
Figure 5. Bone marrow biopsy showing cells with CD117 expression.
Figure 6.
Figure 6. Left ilium bone biopsy showing atypical mast cells.
Figure 7.
Figure 7. Left ilium bone biopsy showing cells with CD117 expression.

Table

Table 1. Pertinent Laboratory Results on Presentation
 
Laboratory testDay 1Reference range
AST: aspartate aminotransferase; ALT: alanine aminotransferase; BUN: blood urea nitrogen.
White blood count (WBC)3.34 - 11 × 103/µL
Hemoglobin11.312 - 16 g/dL
Hematocrit3236-48%
Platelet104150 - 450 × 103/µL
Alkaline phosphatase36240 - 129 U/L
Total bilirubin20.0 - 1.0 mg/dL
AST/ALT38/2310 - 40 U/L
Potassium2.53.5 - 5 mmol/L
BUN128 - 23 mg/dL
Creatinine0.570.5 - 1.0 mg/dL
Total protein5.96.0 - 8.3 gm/dL
Albumin3.13.5 - 5.2 gm/dL
Calcium8.68.5 - 10.2 mg/dL