Journal of Hematology, ISSN 1927-1212 print, 1927-1220 online, Open Access
Article copyright, the authors; Journal compilation copyright, J Hematol and Elmer Press Inc
Journal website https://jh.elmerpub.com

Original Article

Volume 13, Number 6, December 2024, pages 278-284

Methionine Synthase Reductase A66G Variant in Pediatric Acute Lymphoblastic Leukemia Patients

Tables

↓  Table 1. Subtypes of ALL and Gender in the Pediatric Samples
 
Variable Children P value
ALL: acute lymphoblastic leukemia; B-ALL: B-cell ALL; T-ALL: T-cell ALL.
Subtypes
  B-ALL 66 (76.7%) 0.001
  T-ALL 20 (23.3%)
Gender
  Male 57 (66.3%) 0.001
  Female 29 (33.7%)

 

↓  Table 2. Comparison of the WBCs and Blast Cells Counts According to ALL Subtypes
 
Parameter B-ALL, mean ± SD T-ALL, mean ± SD P value
ALL: acute lymphoblastic leukemia; B-ALL: B-cell ALL; T-ALL: T-cell ALL; WBC: white blood cell; RBC: red blood cell; PLT: platelet; SD: standard deviation.
Total WBCs count (× 109/L) 41.1 ± 32.4 173.1 ± 41.8 < 0.0005
RBCs count (× 1012/L) 3.9 ± 0.7 3.9 ± 0.7 0.814
Hemoglobin (g/dL) 8.4 ± 5.6 8.3 ± 1.9 0.624
PLT count (× 109/L) 43.5 ± 5.1 54.5 ± 37.6 0.354
Blast (%) 59.1 ± 15.8 72.1 ± 12.9 0.039

 

↓  Table 3. Distribution of MTRR (A66G) Genotypes Among Children
 
Genotype Patients Control P value
MTRR: methionine synthase reductase.
AA 40 (46.51%) 59 (39.33%) 0.082
AG 42 (48.84%) 60 (40.00%)
GG 4 (4.65%) 31 (20.67%)

 

↓  Table 4. Comparison of Hematological Parameters in ALL Patients With Wild and Mutant Type MTRR Alleles
 
Parameter Wild (n = 39), mean ± SD Mutant (n = 47), mean ± SD P value
MTRR: methionine synthase reductase; ALL: acute lymphoblastic leukemia; WBC: white blood cell; RBC: red blood cell; PLT: platelet; SD: standard deviation.
Total WBCs count (× 109/L) 58.8 ± 11.7 69.9 ± 10.3 0.606
RBCs count (× 1012/L) 3.6 ± 0.9 3.8 ± 0.8 0.058
Hemoglobin (g/dL) 8.5 ± 6.7 8.6 ± 3.5 0.727
PLT count (× 109/L) 45.6 ± 4.43 55.8 ± 6.43 0.188
Blast (%) 61.4 ± 21.4 69.1 ± 19.2 0.241