J Hematol

Journal of Hematology, ISSN 1927-1212 print, 1927-1220 online, Open Access

Article copyright, the authors; Journal compilation copyright, J Hematol and Elmer Press Inc

Journal website https://jh.elmerpub.com

Original Article

Volume 13, Number 6, December 2024, pages 278-284

Methionine Synthase Reductase A66G Variant in Pediatric Acute Lymphoblastic Leukemia Patients

Tables

**Table 1.** Subtypes of ALL and Gender in the Pediatric Samples
Variable	Children	P value
ALL: acute lymphoblastic leukemia; B-ALL: B-cell ALL; T-ALL: T-cell ALL.
Subtypes
B-ALL	66 (76.7%)	0.001
T-ALL	20 (23.3%)	0.001
Gender
Male	57 (66.3%)	0.001
Female	29 (33.7%)	0.001

**Table 2.** Comparison of the WBCs and Blast Cells Counts According to ALL Subtypes
Parameter	B-ALL, mean ± SD	T-ALL, mean ± SD	P value
ALL: acute lymphoblastic leukemia; B-ALL: B-cell ALL; T-ALL: T-cell ALL; WBC: white blood cell; RBC: red blood cell; PLT: platelet; SD: standard deviation.
Total WBCs count (× 10⁹/L)	41.1 ± 32.4	173.1 ± 41.8	< 0.0005
RBCs count (× 10¹²/L)	3.9 ± 0.7	3.9 ± 0.7	0.814
Hemoglobin (g/dL)	8.4 ± 5.6	8.3 ± 1.9	0.624
PLT count (× 10⁹/L)	43.5 ± 5.1	54.5 ± 37.6	0.354
Blast (%)	59.1 ± 15.8	72.1 ± 12.9	0.039

**Table 3.** Distribution of *MTRR* (A66G) Genotypes Among Children
Genotype	Patients	Control	P value
MTRR: methionine synthase reductase.
AA	40 (46.51%)	59 (39.33%)	0.082
AG	42 (48.84%)	60 (40.00%)
GG	4 (4.65%)	31 (20.67%)

**Table 4.** Comparison of Hematological Parameters in ALL Patients With Wild and Mutant Type *MTRR* Alleles
Parameter	Wild (n = 39), mean ± SD	Mutant (n = 47), mean ± SD	P value
MTRR: methionine synthase reductase; ALL: acute lymphoblastic leukemia; WBC: white blood cell; RBC: red blood cell; PLT: platelet; SD: standard deviation.
Total WBCs count (× 10⁹/L)	58.8 ± 11.7	69.9 ± 10.3	0.606
RBCs count (× 10¹²/L)	3.6 ± 0.9	3.8 ± 0.8	0.058
Hemoglobin (g/dL)	8.5 ± 6.7	8.6 ± 3.5	0.727
PLT count (× 10⁹/L)	45.6 ± 4.43	55.8 ± 6.43	0.188
Blast (%)	61.4 ± 21.4	69.1 ± 19.2	0.241